Lauren Kitt and Nick Carter
Angela Weiss/WireImage
"I had the ring in my pocket for two weeks," the Backstreet Boy tells PEOPLE exclusively of his engagement to fitness expert/actress Lauren Kitt.
"I was like, 'I don't want it anymore!' It was driving me insane. I just wanted to get it out of my hands and on to hers."
For the momentous occasion, Carter, 33, took his fiancée, 29, to the Florida Keys where he planned a romantic boat ride to a secluded island – but things did not go as smoothly as expected.
"My boat was in such bad condition because I hadn't used it for, like, six years. It took me five days literally on my hands and knees, scraping up my body [to fix it,]" Carter says. "The engine wasn't complete yet but we still decided to go out."
Despite the engine stalling a few times as they set out to sea Wednesday, Carter and Kitt – along with some close friends and Kitt's father – arrived at a small island Carter had spent time on as a child.
It was there, on the island the couple now refers to as "Engagement Island," that the Backstreet Boy dropped to one knee and presented his girlfriend of over four years with a seven-carat diamond ring from XIV KARATS.
"She said, 'Yes,' and I'm, like, 'I don't know what to do," Carter tells PEOPLE of the proposal. "She said, 'You're supposed to put it on my finger.' So I did. I was in shock."
The proposal came as a surprise to the bride-to-be as well.
"I wasn't expecting it. It just felt very surreal," explains Kitt. "We both are just so happy in love right now and on cloud nine."
And while the couple is excited for their wedding, there are a few other people they must consult before planning their impending nuptials – the band.
"Our first thought was, 'We need to contact the Backstreet Boys and find out when their schedule will permit,'" Kitt says of wedding planning while the band works on a new album and prepares for their sold-out fan cruise in October to celebrate their 20th anniversary.
"It's not up to us. It's up to the schedule. We're just excited and looking forward to the next chapter of our lives."
WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones.
The drug Kadcyla from Roche combines the established drug Herceptin with a powerful chemotherapy drug and a third chemical linking the medicines together. The chemical keeps the cocktail intact until it binds to a cancer cell, delivering a potent dose of anti-tumor poison.
Cancer researchers say the drug is an important step forward because it delivers more medication while reducing the unpleasant side effects of chemotherapy.
"This antibody goes seeking out the tumor cells, gets internalized and then explodes them from within. So it's very kind and gentle on the patients — there's no hair loss, no nausea, no vomiting," said Dr. Melody Cobleigh of Rush University Medical Center. "It's a revolutionary way of treating cancer."
Cobleigh helped conduct the key studies of the drug at the Chicago facility.
The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy. These patients have tumors that overproduce a protein known as HER-2. Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute.
The approval will help Roche's Genentech unit build on the blockbuster success of Herceptin, which has long dominated the breast cancer marketplace. The drug had sales of roughly $6 billion last year.
Genentech said Friday that Kadcyla will cost $9,800 per month, compared to $4,500 per month for regular Herceptin. The company estimates a full course of Kadcyla, about nine months of medicine, will cost $94,000.
FDA scientists said they approved the drug based on company studies showing Kadcyla delayed the progression of breast cancer by several months. Researchers reported last year that patients treated with the drug lived 9.6 months before death or the spread of their disease, compared with a little more than six months for patients treated with two other standard drugs, Tykerb and Xeloda.
Overall, patients taking Kadcyla lived about 2.6 years, compared with 2 years for patients taking the other drugs.
FDA specifically approved the drug for patients with advanced breast cancer who have already been treated with Herceptin and taxane, a widely used chemotherapy drug. Doctors are not required to follow FDA prescribing guidelines, and cancer researchers say the drug could have great potential in patients with earlier forms of breast cancer
Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death. The drug can also cause severe birth defects and should not be used by pregnant women.
Kadcyla was developed by South San Francisco-based Genentech using drug-binding technology licensed from Waltham, Mass.-based ImmunoGen. The company developed the chemical that keeps the drug cocktail together and is scheduled to receive a $10.5 million payment from Genentech on the FDA decision. The company will also receive additional royalties on the drug's sales.
Shares of ImmunoGen Inc. rose 2 cents to $14.32 in afternoon trading. The stock has ttraded in a 52-wek range of $10.85 to $18.10.
NEW YORK (Reuters) - U.S. stocks rose on Friday as Dow component Hewlett-Packard surged on strong results and comments from Fed officials allayed fears that the central bank would curtail its stimulus measures.
Federal Reserve Chairman Ben Bernanke downplayed worries that the Fed has fueled asset bubbles that could hurt the economy in a private meeting with bond dealers and investors earlier this month, Bloomberg reported on Friday.
Bernanke's view helped ease fears that the central bank may end its easy money policies. Minutes from the Federal Reserve's January meeting hit markets on Wednesday as investors interpreted divergent opinions on the benefit of stimulus as a sign the measures may be halted sooner than thought.
"They are in uncharted territory with divergent views," said Jack Ablin, chief investment officer at BMO Private Bank in Chicago. "I could see some pretty heated opinions on what the ultimate outcome is, so I do believe there is dissension."
Hewlett-Packard Co
The Dow Jones industrial average <.dji> gained 119.95 points, or 0.86 percent, to 14,000.57 at the close. The Standard & Poor's 500 Index <.spx> rose 13.18 points, or 0.88 percent, to 1,515.60. The Nasdaq Composite Index <.ixic> added 30.33 points, or 0.97 percent, to end at 3,161.82.
With Bernanke's reported comments much on their minds in Friday's session, investors will want the Fed chairman to reiterate his remarks publicly when he speaks before the Senate Banking Committee on Tuesday. That would echo comments made by two top Fed officials on Friday.
Boston Fed President Eric Rosengren and Fed Governor Jerome Powell both defended the U.S. central bank's asset-buying program, arguing that the policy helps the U.S. economy.
The S&P 500 shed 1.9 percent over the previous two sessions, its worst two-day drop since early November, following the release of the Fed's minutes on Wednesday. The selloff marked the end of seven back-to-back weeks of gains for stocks.
For the week, the S&P 500 slipped 0.3 percent and the Nasdaq lost nearly 1 percent. Only the Dow ended the week with a gain - up just 0.1 percent.
HP's results come near the end of a relatively strong earnings season in which 70 percent of S&P 500 companies beat analysts' expectations, compared with a 62 percent average since 1994 and 65 percent over the past four quarters, according to Thomson Reuters data.
"Overall, the earnings supports were better than expected in this cycle," said Peter Jankovskis, co-chief investment officer at OakBrook Investments LLC in Lisle, Illinois. "We may see the market rising during the month of March."
Fourth-quarter earnings for S&P 500 companies are estimated to have risen 6 percent, according to the data, above a 1.9 percent forecast at the start of the earnings season.
But with only a handful of companies left to report earnings, investors are looking ahead to the possibility of hefty automatic budget cuts that could happen on March 1.
A large option investor appeared to be adjusting a bearish view on the SPDR S&P 500 Trust fund
"An institutional investor appears to be rolling down and increasing in size a defensive hedge timed to match the March 1 deadline for the sequester," said Henry Schwartz, president of options analytics firm Trade Alert.
The trader sold 132,000 $149 to $150 weekly put spreads for 22 cents as shares of the exchange-traded fund had traded near $151.14 on Friday morning. The transaction entailed the sale of $150 weekly puts to buy the $149 weekly puts. In addition, the investor purchased another 42,000 $149 weekly puts, which increases the size of the hedge to 174,000 contracts.
"It is likely this large position protects an existing underlying long position in a portfolio," Schwartz said.
In another political risk factor, Italians go to the polls this weekend in an election that could threaten reforms in the indebted country. Silvio Berlusconi's resurgence has thrown the vote wide open, with deep uncertainty over whether the poll can produce the strong government the country needs.
Inconclusive Greek elections last year sparked a protracted selloff and a period of uncertainty in markets.
In the tech sector, Marvell Technology Group Ltd
Texas Instruments Inc
The PHLX semiconductor index <.sox> gained 2.1 percent.
"Dividends growing are another way the market's level is justified, if not especially attractive at these levels," said Rex Macey, chief investment officer of Wilmington Trust in Atlanta, who manages about $20 billion in assets.
On the downside, Abercrombie & Fitch dropped 4.5 percent to $46.86 after the youth-oriented clothing retailer reported a drop in fourth-quarter comparable sales, even as its latest quarterly earnings topped estimates.
Insurer American International Group Inc posted fourth-quarter results that beat analysts' expectations. AIG's stock advanced 3.1 percent to $38.45.
About three stocks rose for every one that fell on both the New York Stock Exchange and Nasdaq.
Around 5.8 billion shares changed hands on the New York Stock Exchange, the Nasdaq and NYSE MKT, below the 20-day moving average of around 6.51 billion shares.
(Additional Reporting by Ryan Vlastelica and Doris Frankel; Editing by Kenneth Barry and Jan Paschal)
Todd Heisler/The New York Times
Hu Ping, the editor of a pro-democracy journal in New York, has not seen his aging parents in decades because of passport restrictions.
BEIJING — Flush with cash and eager to see the world, millions of middle-class Chinese spent the 10-day Lunar New Year holiday that ended on Monday in places like Paris, Bangkok and New York. Last year, Chinese made a record 83 million trips abroad, 20 percent more than in 2011 and a fivefold increase from a decade earlier.
Sun Wenguang, a retired economics professor from China’s Shandong Province, was not among those venturing overseas, however. And not by choice. An author whose books offer a critical assessment of Communist Party rule, Mr. Sun, 79, has been repeatedly denied a passport without explanation.
“I’d love to visit my daughter in America and my 90-year-old brother in Taiwan but the authorities have other ideas,” he said. “I feel like I’m living in a cage.”
Mr. Sun is among the legions of Chinese who have been barred from traveling abroad by a government that is increasingly using the issuance of passports as a cudgel against perceived enemies — or as a carrot to encourage academics whose writings have at times strayed from the party line to return to the fold.
“It’s just another way to punish people they don’t like,” said Wu Zeheng, a government critic and Buddhist spiritual leader from southern Guangdong Province whose failed entreaties to obtain a passport have prevented him from accepting at least a dozen speaking invitations in Europe and North America.
China’s passport restrictions extend to low-level military personnel, Tibetan monks and even the security personnel who process passport applications. “I feel so jealous when I see all my friends taking vacations in Singapore or Thailand but the only way I could join them is to quit my job,” said a 28-year-old police detective in Beijing.
Lawyers and human rights advocates say the number of those affected has soared in recent years, with Tibetans and Uighurs, the Turkic-speaking minority from China’s far west, increasingly ineligible for overseas fellowships, speaking engagements or the organized sightseeing groups that have ferried planeloads of Chinese to foreign capitals.
Although the government does not release figures on those who have been denied passports, human rights groups suggest that at least 14 million people — mostly those officially categorized as ethnic Uighurs and Tibetans — have been directly affected by the restrictions as have hundreds of religious and political dissidents. A representative of the Exit-Entry Administration of the Public Security Bureau declined to discuss the nation’s passport policies.
The seemingly arbitrary restrictions also affect overseas Chinese who had grown accustomed to frequent visits home. Scores of Chinese expatriates have been denied new passports by Chinese embassies when their old ones expire, while others say they are simply turned away after landing in Beijing, Shanghai or Hong Kong. After finding their names on a blacklist, border control officers will escort returnees on to the next outbound flight. Even if seldom given explanations for their expulsions, many of those turned away suspect it is punishment for their anti-government activism abroad.
“Compared to other forms of political persecution, the denial of the right to return home seems like a small evil,” said Hu Ping, the editor of a pro-democracy journal in New York who has not seen his aging parents in decades. “But it’s a blatant violation of human rights.”
Even those carrying valid passports are subject to the whims of the authorities. On Feb. 6, Wang Zhongxia, 28, a Chinese activist who had planned to meet the Burmese opposition leader Daw Aung San Suu Kyi, was barred from boarding a Myanmar-bound flight from the southern city of Guangzhou. Four days earlier, Ilham Tohti, an academic and vocal advocate for China’s ethnic Uighurs, was prevented from leaving for the United States.
Mr. Tohti, who was set to begin a yearlong fellowship at Indiana University, said he was interrogated at Beijing International Airport for nearly 12 hours by officers who refused to explain his detention. Speaking from his apartment in the capital, Mr. Tohti said Uighurs have long faced difficulties in obtaining passports but that the authorities have made it nearly impossible in recent years. “We feel like second-class citizens in our own country,” he said.
For decades after the Communists came to power in 1949, most Chinese could only dream of traveling abroad; the handful who managed to leave often escaped by evading border guards and swimming across shark-infested waters to what was then British-ruled Hong Kong. As China opened up to the outside world in the early 1980s, the government began providing passports and exit visas to graduate students with acceptance letters from universities overseas.
Before he gets down to the business of hosting on Sunday's 85th Annual Academy Awards, MacFarlane 39, posed in a lighthearted set of promotional photos, leading up to Hollywood's biggest night.
In one of the shots, the Family Guy creator is holding a tub of popcorn – but in the next, the kernels are flying everywhere, much to the star's delight. In another shot, MacFarlane does his best impression of Oscar himself.
MacFarlane will make his Academy Awards hosting debut live on ABC from the Dolby Theatre in Hollywood.
Previously, MacFarlane shot a silly video promo pretending to be Daniel Day-Lewis.
Seth MacFarlane
BOB D'AMICO / ABC
ATLANTA (AP) — It turns out this year's flu shot is doing a startlingly dismal job of protecting senior citizens, the most vulnerable age group.
The vaccine is proving only 9 percent effective in people 65 and older against the harsh strain of the flu that is predominant this season, the Centers for Disease Control and Prevention said Thursday.
Health officials are baffled as to why this is so. But the findings help explain why so many older people have been hospitalized with the flu this year.
Despite the findings, the CDC stood by its recommendation that everyone over 6 months get flu shots, the elderly included, because some protection is better than none, and because those who are vaccinated and still get sick may suffer less severe symptoms.
"Year in and year out, the vaccine is the best protection we have," said CDC flu expert Dr. Joseph Bresee.
Overall, across the age groups studied, the vaccine's effectiveness was found to be a moderate 56 percent, which means those who got a shot have a 56 percent lower chance of winding up at the doctor with the flu. That is somewhat worse than what has been seen in other years.
For those 65 and older, the vaccine was only 27 percent effective against the three strains it is designed to protect against, the worst level in about a decade. It did a particularly poor job against the tough strain that is causing more than three-quarters of the illnesses this year.
It is well known that flu vaccine tends to protect younger people better than older ones. Elderly people have weaker immune systems that don't respond as well to flu shots, and they are more vulnerable to the illness and its complications, including pneumonia.
But health officials said they don't know why this year's vaccine did so poorly in that age group.
One theory, as yet unproven, is that older people's immune systems were accustomed to strains from the last two years and had more trouble switching gears to handle this year's different, harsh strain.
The preliminary data for senior citizens is less than definitive. It is based on fewer than 300 people scattered among five states.
But it will no doubt surprise many people that the effectiveness is that low, said Michael Osterholm, a University of Minnesota infectious-disease expert who has tried to draw attention to the need for a more effective flu vaccine.
Among infectious diseases, flu is considered one of the nation's leading killers. On average, about 24,000 Americans die each flu season, according to the CDC.
This flu season started in early December, a month earlier than usual, and peaked by the end of year. Hospitalization rates for people 65 and older have been some of the highest in a decade, at 146 per 100,000 people.
Flu viruses tend to mutate more quickly than others, so a new vaccine is formulated each year to target the strains expected to be the major threats. CDC officials have said that in formulating this year's vaccine, scientists accurately anticipated the strains that are circulating this season.
Because of the guesswork involved, scientists tend to set a lower bar for flu vaccine. While childhood vaccines against diseases like measles are expected to be 90 or 95 percent effective, a flu vaccine that's 60 to 70 percent effective in the U.S. is considered pretty good. By that standard, this year's vaccine is OK.
For senior citizens, a flu vaccine is considered pretty good if it's in the 30 to 40 percent range, said Dr. Arnold Monto, a University of Michigan flu expert.
A high-dose version of the flu shot was recently made available for those 65 and older, but the new study was too small to show whether that has made a difference.
The CDC estimates are based on about 2,700 people who got sick in December and January. The researchers traced back to see who had gotten shots and who hadn't. An earlier, smaller study put the vaccine's overall effectiveness at 62 percent, but other factors that might have influenced that figure weren't taken into account.
The CDC's Bresee said there is a danger in providing preliminary results because it may result in people doubting — or skipping — flu shots. But the figures were released to warn older people who got shots that they may still get sick and shouldn't ignore any serious flu-like symptoms, he said.
___
Online:
CDC report: http://www.cdc.gov/mmwr
NEW YORK (Reuters) - U.S. stocks fell for a second straight day on Thursday and the S&P 500 posted its worst two-day loss since November after reports cast doubt over the health of the U.S. and euro-zone economies.
But a late-day rally helped stocks erase some of their losses with most of the pullback concentrated in the technology- heavy Nasdaq. The move suggested investors were still willing to buy on dips even after the sharp losses in the last session.
In Europe, business activity indexes dealt a blow to hopes that the euro zone might emerge from recession soon, showing the downturn across the region's businesses unexpectedly grew worse this month.
"The PMI numbers out of Europe were really a blow to the market," said Jack De Gan, chief investment officer at Harbor Advisory in Portsmouth, New Hampshire. "The market was expecting signs that recovery is still there, but the numbers just highlighted that the euro-zone problem is still persistent."
U.S. initial claims for unemployment benefits rose more than expected last week while the Federal Reserve Bank of Philadelphia said its index of business conditions in the U.S. mid-Atlantic region fell in February to the lowest in eight months.
Gains in Wal-Mart Stores Inc
The Dow Jones industrial average <.dji> fell 46.92 points, or 0.34 percent, to 13,880.62 at the close. The Standard & Poor's 500 Index <.spx> lost 9.53 points, or 0.63 percent, to 1,502.42. The Nasdaq Composite Index <.ixic> dropped 32.92 points, or 1.04 percent, to close at 3,131.49.
The two-day decline marked the U.S. stock market's first sustained pullback this year. The Standard & Poor's 500 has fallen 1.8 percent over the period and just managed to hold the 1,500 level on Thursday. Still, the index is up 5.3 percent so far this year.
The abrupt reversal in markets, which started on Wednesday after minutes from the Federal Reserve's January meeting suggested stimulus measures may end earlier than thought, looks set to halt a seven-week winning streak for stocks that had lifted the Dow and the S&P 500 close to all-time highs.
Wall Street will soon face another test with the upcoming debate in Washington over the automatic across-the-board spending cuts put in place as part of a larger congressional budget fight. Those cuts, set to kick in on March 1 unless lawmakers agree on an alternative, could depress the economy.
Semiconductor stocks ranked among the weakest of the day, pressuring the Nasdaq as the Philadelphia Semiconductor Index <.sox> fell 1.8 percent. Intel Corp
The Dow also got a helping hand from personal computer maker Hewlett-Packard Co
Shares of Boeing Co
In other company news, shares of supermarket operator Safeway Inc
Shares of VeriFone Systems Inc
Of the 427 companies in the S&P 500 that have reported results so far, 69.3 percent have exceeded analysts' expectations, compared with a 62 percent average since 1994 and 65 percent over the past four quarters, according to Thomson Reuters data through Thursday morning.
Fourth-quarter earnings for S&P 500 companies are estimated to have risen 5.9 percent, according to the data, above a 1.9 percent forecast at the start of the earnings season.
Berry Petroleum Co
About two stocks fell for everyone that rose on the New York Stock Exchange and Nasdaq. About 7.64 billion shares changed hands on the New York Stock Exchange, the Nasdaq and NYSE MKT, well above the 20-day moving average of around 6.6 billion shares.
(Editing by Jan Paschal)
WASHINGTON — Just days before Iran enters its first nuclear talks with the West since the summer, international nuclear inspectors said Thursday that the country had begun installing a new generation of equipment to enrich uranium that could speed its ability to produce nuclear fuel.
The installation, at the Natanz nuclear enrichment center, which is highly vulnerable to bombing, came after a half-decade of delays in production made worse by Western sanctions and sabotage. The new centrifuges are four to five times more powerful than the aging design that Iran has been using for years. The advance has worried American, European and Israeli officials who fear Iran might decide to race toward making fuel for nuclear weapons.
But the evidence collected by the International Atomic Energy Agency, as recently as Tuesday, suggests that the Iranian authorities are deliberately slowing the accumulation of medium-enriched uranium, which could most quickly be converted to bomb fuel. According to the agency, the Iranian nuclear authorities have diverted much of that production to make specialized fuel for a research reactor — more fuel than they need to power the reactor.
The result is that Iran has delayed the day when it would reach what Israel’s prime minister, Benjamin Netanyahu, defined as his latest “red line”: the accumulation of enough medium-enriched fuel to make a single nuclear weapon. Mr. Netanyahu spoke of the line — the point Iran would not be allowed to pass — at the United Nations last fall, when it appeared that Iran would accumulate that amount — about 240 or 250 kilograms of uranium enriched to 20 percent purity — by early this summer. The agency’s latest evidence pushes that date to the fall, allowing more time for diplomacy.
Still on Thursday the prime minister’s spokeswoman called the new assessment of the inspectors “a very grave report, which proves that Iran is continuing to make rapid progress toward the red line.” She added that “the first subject” Mr. Netanyahu will discuss with President Obama during his planned visit to Israel next month is preventing Iran from obtaining nuclear arms.
The report also indicated no evidence of any explosion or other setback at the deep-underground nuclear facility called Fordo, which is regularly visited by inspectors. Reports, fueled by a right-wing Web site with ties to the Iranian opposition, had suggested a major explosion at the site; that report, which appeared in a number of European newspapers, now appears to have been false.
The new centrifuges are known as IR-2, short for Iranian second generation. Iran’s president, Mahmoud Ahmadinejad, disclosed research on the equipment more than six years ago, boasting that it would quadruple Iran’s enrichment powers.
Testing the new centrifuges at the Natanz site in the Iranian desert began at a pilot plant in early 2008, and reached an advanced stage in 2011. But until recently, a range of technical problems had delayed their introduction into the cavernous underground halls of the production plant, which is roughly half the size of the Pentagon.
One mystery is why Iran is installing the new centrifuges at Natanz. It is just barely underground, and vulnerable to air attack. It is also the plant that was struck by a series of American and Israeli cyberattacks, part of a classified program called Olympic Games that resulted in a temporary setback for the program.
Centrifuges spin extraordinarily fast to capture the rare isotope of uranium that can fuel atom bombs or nuclear reactors.
The IR-2 is based on Pakistan’s second-generation model. The rotor of the Pakistani machine, made of superhard steel, can spin much faster than the original model, speeding the pace of enrichment.
But Iran had great difficulty building the machines and obtaining the special steel. Mostly in secret, it instead developed its own version, the IR-2. It is partly indigenous, signaling that the Iranians have achieved new levels of technical skill.
Western experts say the IR-2 is roughly half the height of Iran’s original centrifuge but spins twice as fast. Its rotor is made not of superstrong steel but carbon fibers, which Iran has also experienced difficulty making and importing from abroad because of Western sanctions.
If they work properly, 1,000 of the new machines would be able to enrich the same amount of uranium as 4,000 to 5,000 of the old model. Iran currently has about 10,000 of the old machines spinning away at Natanz.
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